Heart Disease & High Blood Pressure

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The content of this article is from the book “The Comprehensive Guide to Glutathione”
by Dr. Jimmy Gutman MD FACEP

The immune system coordinates a variety of specialized cells to fight off infection and other threats. The healthy growth and activity of these cells depends upon the availability of glutathione. Glutathione is at the heart of most immune functions, explaining why low levels are seen in many diseases. This is best exemplified by AIDS, which is characterized by a severely compromised immune system. 

Raising and maintaining glutathione levels can minimize the risk of these diseases. Although only very ill people are severely deficient in glutathione, those in good or fair health will benefit from glutathione supplementation, especially considering the environmental toxins and

drug-resistant bacteria we’re exposed to these days. 

The use of glutathione supplementation fights all kind of diseases from respiratory to auto immune to degenerative diseases.

Without question, the best type of preventive medicine is an optimized immune system, and a critical means to optimize it is by feeding it glutathione.

Glutathione as a dietary supplement.

We must first clarify an important, frequently misunderstood part of the glutathione story.

Upon learning about glutathione for the first time, many people go to their health store, buy it, and start dosing themselves. However, while glutathione is freely available in this form, this sort of oral, ingested glutathione will have negligible effects on your health. The product decomposes rapidly in the digestive system and is quickly removed from the gut. Apart from a few very specific instances, glutathione cannot be introduced into the body in this way. It must be made within your cells -which is where it’s naturally found. The effective way to stimulate the production of glutathione is to provide your body with the basic elements it needs to make glutathione by itself. Some pharmaceutical medications, such as N-acetyl-cysteine (NAC), have been developed to provide these precursors. There are also natural ways to increase glutathione levels, in particular the use of denatured (bioactive) whey proteins.

These are discussed throughout this website.

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Angina ~ Testimonial.

Why worry about glutathione?” The answer is simple: “Disease prevention, quality of life, longevity, sense of well-being.” Or, to put it more clearly, “Stay alive. as long as possible and enjoy good health until the end.

From the book “Glutathione Your Key to Health” Jimmy Gutman MD/Stephen Schettini

ARTERIOSCLEROSIS

Heart disease and stroke are the main cause of death in North America. Both result from the same process — arteriosclerosis, also called atherosclerosis or hardening of the arteries. is such a common disease in the developed world that it has been considered a normal part of the aging process. In fact, overwhelming evidence links it closely to diet and life-style issues such as smoking and lack of exercise, suggesting that this major cause of mortality and morbidity is preventable, or that its progress may be slowed down or even reversed.

Although it is more common in older people, the early stages of this disease are sometimes found in children, and people in their thirties can suffer significant damage.

The consequences of arteriosclerosis are disastrous — heart failure, heart attack, stroke, kidney failure, high blood pressure, impaired circulation, and many other ailments. Additional contributing factors aggravate this condition and must be managed throughout our lives to ensure health and longevity.

Low FIBER

Dietary fiber adds bulk to the feces, which then pass through the intestines more easily, aiding normal bowel function. Low-fiber diets affect fat absorption and increase cholesterol levels. A high-fiber diet is critical. Adequate fiber can be found by eating a variety of fruits, vegetables and grains every day.

To understand how glutathione can help prevent and treat this disease, let’s look at how arteriosclerosis develops. An artery wall has three layers a tough epithelium, a thick muscular mesothelium, and a delicate endothelium. Endothelial lining is especially prone to damage, and thin streaks of fatty deposits can build up there. In the healthy artery, this process is combated by several processes, including our natural antioxidant defenses. In arteries damaged by high blood pressure, stress or cigarette smoking, these fatty deposits accumulate. To heal the damage, the body lays down platelets, calcium and scar tissue. Plaque thickens and makes the area stickier than normal, encouraging the accumulation of additional lipids. Slowly the artery becomes sufficiently clogged to inhibit blood flow, depriving organs, and muscles of oxygen.

HEART DISEASE

Poor circulation affects all organ systems including the brain, kidneys, eyes, and extremities, but its main burden is heart disease. When blood flow to areas of the heart through the coronary arteries is cut off, a heart attack results. The pain of angina comes from heart tissue that cannot get enough oxygen because of insufficient blood flow. A heart with poor blood flow weakens and leads to heart failure. Hardened arteries often lead to high blood pressure, which further compromises the heart.

Physicians try to prevent this downward spiral with medications that lower blood pressure, thin the blood, decrease cholesterol, strengthen heart muscle contractions, and improve arterial blood flow. Surgery can provide a way around blockages. A coronary bypass operation consists of a grafted vein that bypasses the blockage. Angioplasty is a way to squash plaque against the artery wall and make more room for blood to pass through.

STROKE

A stroke is caused by blocked blood flow (ischemia) that deprives the brain of oxygen. All vital organs are prone to ischemia when arteries become narrow and hard. In these cases, it is important to thin the blood and manage cholesterol levels. Occasionally, surgery is performed to remove the buildup of plaque in the arteries leading to the brain.

Both the deprivation of oxygen from brain tissue and its subsequent reintroduction (see reperfusion injury, below) cause significant damage. Neurologists from the University of California (San Francisco) showed the importance of glutathione in protecting the brain from such attack. Animals whose glutathione levels were artificially lowered suffered significantly greater brain damage after a stroke. Neurosurgeons at the University of Washington went further, demonstrating that glutathione depletion also leads to further narrowing of the critical arteries serving those oxygen-starved areas.

CHOLESTEROL AND PLAQUE FORMATION

The process of plaque formation is complex, and it takes years to reach the point of causing symptoms. However, it is clear that certain types of fatty substances are more dangerous than others. LDL, bad cholesterol, leads to plaque formation, while HDL — good cholesterol — prevents it. Other factors increase the danger of these fats, especially oxidative stress.

Oxidation makes fat rancid. In our blood stream this chemical change is called lipid peroxidation and causes fatty deposits to stick to the artery walls.

the corresponding formation of free radicals leads to further lipid peroxidation and subsequent hardening of the arteries. Cigarette smoke releases large amounts of free radicals into the bloodstream, explaining why more smokers die of cardiovascular disease than of lung cancer. For similar reasons, diabetics are also prone to vascular damage.

Researchers have identified many causes of cardiovascular disease. The biochemical changes that result in oxidation of fat, especially LDL-cholesterol, are important, but they are also studying the chemicals involved in the associated inflammatory response, platelet function and cardiac muscle aging. The new field of free-radical biology is revealing a greater than previously thought role for oxidative stress in cardiac disease. Thousands of published articles describe the role of oxidation in arteriosclerosis and huge studies are underway to establish the role of vitamin and mineral supplementation in treating and preventing this disease.

An excellent article published by a combined team of Canadian and Japanese heart researchers reviewed evidence for the role of oxidative stress in acute ischemic heart disease. They suggest that the use of antioxidant therapy prior to procedures such as angioplasty, coronary bypass and thrombolysis may help prevent complications.

Without adequate protective mechanisms to combat free radicals and lipid peroxidation, vascular systems are quickly overcome by atherosclerosis. M.J. Kendall’s team at Birmingham University examined over two thousand patients with confirmed coronary artery disease in a randomized clinical trial. Patients taking antioxidant supplements reduced their risk of cardiovascular disease by 47%. Some cardiologists argue that well-defined clinical trials have not yet proven beyond doubt that antioxidants are essential, but a poll of cardiologists published in the American Journal of Cardiology found that a full 44% of them take antioxidants themselves.

GLUTATHIONE AND ARTERIOSCLEROSIS

The principal antioxidant in our cells is glutathione applies to the endothelial cells of the arteries as well as red blood cells and platelets. University of British Columbia researchers led by Kimberly Cheng showed the connection among cholesterol levels, glutathione levels and plaque formation in the aorta. L.L. Ji, D. DilIon and E. Wu showed that decreasing glutathione levels as we age contribute to the formation of atherosclerosis. Although antioxidants like vitamins C and E are increasingly considered important, the naturally occurring antioxidant in the cell is glutathione. Glutathione also serves to recycle these other antioxidants into their functionally active form.

In determining cardiovascular risk factors, certain tests or markers can indicate the risk or existence of heart disease. Two of these are lipoprotein-a (Lp[a]) and Homocysteine. D. Gavish,J.L. Breslow and other researchers have shown the glutathione-promoting drug NAC to be very effective in lowering Lp[a] levels. reported a 50 to 70% reduction using two to four grams of NAC per day — a considerable dose. Other researchers using more tolerable amounts were less successful at reducing Lp[aJ but have suggested that NAC may influence atherosclerosis in other ways. include reduction of bad cholesterol and inhibition of free radical formation by monocytes — white blood cells that are attracted to platelets.

The association between homocysteine and glutathione metabolism is still being elaborated but will clearly have important repercussions. In an influential review articleJ.S. Stamler and A. Slivka discuss the roles of glutathione, its interaction with homocysteine and the protective effect of glutathione on the vascular system. The Swedes O. Wiklund, G. Fager and their group were able to lower homocysteine levels with NAC.

Decreases circulating cholesterol

Minimizes lipid peroxidation

Protects endothelium from oxidative stress

Diminishes inflammatory response

Stabilizes platelet function, inhibiting oxidation

TABLE 17 — GSH in the fight against arteriosclerosis  

An interesting article in the Japan Heart Journal described a study by A. Usal who measured the red blood cell glutathione of 21 patients with heart attacks and found evident glutathione depletion, indicating that this event presents a major demand for glutathione. Driving this point home, a New England Journal of Medicine article by Blankenberg et al., showed that low glutathione peroxidase levels are associated with an increased risk of heart attack, and that measurements like this may be a way to assess individuals’ prognosis. The team goes on to say that increasing glutathione peroxidase activity might lower the risk of heart attack.

GSH AND CHOLESTEROL

Undenatured whey proteins raise cellular glutathione and some of them — including Immunocal — may contain unusually high levels of lactoferrin, an important protein known to prevent oxidation of LDL-cholesterol. In addition, increased glutathione levels have been shown to improve the reduction of overall cholesterol levels by raising the activity of the enzyme cholesterol hydroxylase. X. Zhang and A.C. Beynen compared various proteins that reduce cholesterol in the blood and liver. Their results showed that whey proteins were more effective than other milk proteins or amino acid mixtures. The authors suggest that the lower cholesterol levels result from the inhibition of cholesterol synthesis in the liver.

Researchers have shown that selenium levels correlate well with levels of HDL (good) cholesterol. In a double-blind study, P.V. Luoma’s team was able to improve the ratio of good to bad cholesterol in healthy subjects by feeding them selenium supplements. Selenium’s only biological activity takes place in the formation of glutathione peroxidase and it is through this action that selenium exerts its positive effects. Italians G. Franceschini andJ.P. Werba had similar success altering HDL/ LDL ratios using NAC (N -acetylcysteine).

GSH AND REPERFUSION INJURY

If a blood clot deprives tissue of blood and oxygen for more than a very brief period, its ability to produce life-giving energy is compromised. The immune system responds by building up neutrophils, a type of white blood cell, further compounding the damage by releasing even more products of oxidation. When bypass surgery or thrombolytic drugs break down the clot and re-establish oxygen flow, the tissues are said to be “reperfused.” But when the fresh blood floods into the starved tissue, it responds with a surge of energy production that places exceptionally heavy oxidative stress on the tissue at the very time that its antioxidant resources have been depleted, paradoxically causing further damage. condition is called reperfusion injury.

Pharmacologists such as KS. Kilgore and B.R. Lucchesi from the University of Michigan long ago suggested the antioxidants should be administered alongside thromobolytic therapy. Cardiologists at the University of Brescia in Italy have shown significant glutathione depletion after cardiac ischemia, and the ability of NAC to combat this depletion.

GSH AND CIRCULATION

There are many other ways in which glutathione protects blood vessels, but they exceed the scope of this book. *They involve the role of glutathione in maintaining smooth muscle tone in the vessel wall, the shifts, and balance in substances including prostaglandins, leukotrienes, thromboxanes, and platelet factors.

CONCLUSION

Glutathione has been shown to diminish the oxidation of fats (lipid peroxidation), decrease circulating cholesterol, minimize the inflammatory response around arteriosclerotic plaque, stabilize platelets and protect the sensitive lining of the arteries. These are all important ways to combat hardening of the arteries and subsequent heart disease. Glutathione also diminishes damage to oxygen-deprived tissue during ischemia, and also during the subsequent complications of reperfusion.

The use of glutathione supplementation fights all kind of diseases from respiratory to auto immune to degenerative diseases.

Without question, the best type of preventive medicine is an optimized immune system, and a critical means to optimize it is by feeding it glutathione.

This is not the same glutathione that you see at the health food store. This is glutathione precursor. It’s very different because glutathione must be made inside your cells and the precursor is the food your cells   require to make its own glutathione as nature intended. That is the most natural and effective approach to boost your immune system.

It’s all natural with NO side effect. 

Want to know if this is for you? 

You can try it for only $10.00 (5-day sample)

Just send me a text here 703-895-0496 with the hashtag “sample” and I will send you a form to fill out, so I know where to send it.

Feel Normal Again!

Cardiovascular disease has had a huge impact on our population. It is to a great degree preventable, and strategies for raising glutathione should go hand-in-hand with a responsible diet and lifestyle. Such measures can prevent and may even help reverse this all-too-common illness.