Male Infertility

Click on the picture below to watch about the science of glutathione:

The content of this article is from the book “The Comprehensive Guide to Glutathione”
by Dr. Jimmy Gutman MD FACEP

“Glutathione depletion leads to Oxidative Stress leads to Inflammation leads to Oxidation, pain, discomfort, toxicity, diseases, stress and more…”

Many complicated factors play a part in the infertility that affects about one fifth of American couples. Ovulatory dysfunction accounts for 20%, tubal dysfunction for 30% and abnormal cervical mucus for 5%. These are all female problems. But male sperm disorders account for 35% of cases. problem may be low sperm count or another abnormality of the sperm, such as impaired swimming ability.

A growing body of evidence implies that oxidative stress may cause loss of sperm function. Sperm generate an excess amount of oxyradicals, and these reactive oxygen molecules may lead to lipid peroxidation (oxidation of fatty substances) in the cell wall of the sperm itself. This leads to poor movement characteristics of the sperm and their impaired ability to fuse with the female’s ova or egg. This understanding has opened doors for the development of innovative techniques in the treatment of male infertility.

Patients with idiopathic male infertility were compared to fertile volunteers by measuring oxidative stress, antioxidant activity and glutathione levels. Urologist I. Alkan and his team found significant differences among all parameters of both groups, suggesting that oxidation may cause infertility. Similar studies conducted by F.R. Ochsendorf at the Center of Dermatology and Andrology in Germany support these findings.

A group of reproductive biology scientists led by D.S. Irvine in Edinburgh, Scotland, is raising glutathione contents in male infertility patients. In a paper entitled ‘Glutathione for male infertility,’ he showed that glutathione seems to act at the epididymis and during sperm formation as well as improving the function of ejaculated spermatozoa. Another German team headed by T. Oeda experimented with NAC (N -acetylcysteine) and showed that it reduced oxidative stress and improved impaired sperm function.

A. Lenzi’s team at the University Laboratory of Seminology and Reproduction in Rome has published many papers on the use of injectable glutathione in a variety of infertile males. These studies were human double-blind, cross-over studies and the therapy had consistently positive effects on sperm motility, morphology (structure), and semen quality.

There should be a protein source that would help people systematically, meaning the entire system. For some reason people system is failing and it’s a system wide failure. So there must be something wrong at the cellular level. So it must be some type of protein source that would correct this. (Nutritional research project) Funded by the Canadian government.

lutathione is the utmost detoxifying agent. The first thing it does is get rid of the harmful toxins known as free radicals. As you’ve already seen, free radicals wreak havoc by stealing molecules from healthy cells, thus, damaging such cells. But there’s something you need to keep in mind. Free radicals are just some of the toxins in your body. There are other toxins such as metabolic waste, heavy metals and lipid peroxides that your body still needs to eliminate.

Glutathione eliminates such toxins via a mechanism known as conjugation. This is where glutathione binds itself to the toxin at a specific site and makes it water-soluble. This neutralizes the toxin and enables it to be easily secreted from your body.

If you look at glutathione closely, you’ll notice that it does 3 important things as far as the detoxification process is concerned. First, it neutralizes free radicals. Second, it helps other cells neutralize free radicals by recycling them and third, it neutralizes other toxins in your body. All these roles make it possible for your body to function properly.

Glutathione is produced by your body. It is something that comes from within and unfortunately, many people lack the enzyme that leads to the production of glutathione. Also, when it comes to detoxification, glutathione is quickly depleted especially during the first phase of detoxification. Thus, if you have it but it is not enough, your body will not be able to detoxify as it should.

Thus, in order to successfully detoxify your body and get rid of harmful toxins that cause disease, it is imperative that you raise your levels of glutathione. So what can you do to increase your glutathione levels?

From the book “Glutathione Your Key to Health” Jimmy Gutman MD/Stephen Schettini

Glutathione’s importance to your health cannot be overstated. Your immune system is constantly on the prowl for pathogens — agents of cellular damage, toxicity and disease. To neutralize them the body needs a ready supply of glutathione. If it doesn’t have enough, some of the invaders will get through, infecting the body and/or contributing to aging, long-term accumulative damage — even eventual cancer. We can’t avoid illness and aging altogether — though a few scientists are pursuing the age-old dream of immortality — but by keeping our intracellular glutathione levels up we also keep our immune system on the ball and fully armed. Glutathione is fundamental to the immune response… In the last twenty years the volume of research into Glutathione has grown immensely. A huge variety of theoretical papers, bench-top laboratory experiments, epidemiological studies, animal projects and — most importantly — clinical trials on humans, has linked glutathione to an extraordinary variety of illnesses. Tie list is long and would be hard to believe were it not for the strength and credibility of the research. However, it is now clear that glutathione’s role in the immune response, detoxification and antioxidation is pivotal. Without it, many bodily processes would fail… We call Glutathione the master antioxidant because it replenishes the action of many other antioxidants. When vitamins C and E pick up an oxyradical they must hand it off to the Glutathione system so they are free to go back and get others. Glutathione similarly neutralizes peroxide and lipoic acid. In fact, all of these antioxidants help to neutralize each other, and glutathione is at the center of cellular antioxidation. It is Glutathione — not the vitamin — that ultimately neutralizes the radical. A Glutathione molecule encounters a destructive, positively-charged hydroxyl radical and gives it an electron, turning it into harmless water…”

Glutathione therapy for male infertility
Lenzi A, Lombardo F, Gandini L, Culasso F, Dondero F. [Arch Androl 1992 Jul-Aug;29(1):65-8]
Eleven infertile men were treated with glutathione (600 mg/day IM) for 2 months. The patients were suffering from dyspermia associated with various andrological pathologies. Standard semen and computer analyses of sperm motility were carried out before treatment and after 30 and 60 days of therapy. Glutathione exerted significant effect on sperm motility patterns. Glutathione appears to have a therapeutic effect on some andrological pathologies causing male infertility.

Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility
Lenzi A, Culasso F, Gandini L, Lombardo F, Dondero F. [Hum Reprod 1993 Oct;8(10):1657-62]
Glutathione therapy was used for 2 months in a placebo-controlled double-blind cross-over trial of 20 infertile patients with dyspermia associated with unilateral varicocele (VAR) or germ-free genital tract inflammation (INF). Glutathione therapy demonstrated a statistically significant positive effect on sperm motility, in particular on the percentage of forward motility, the kinetic parameters of the computerized analysis and on sperm morphology. The findings of this study indicate that glutathione therapy could represent a possible therapeutical tool for both of the selected andrological pathologies.
Publication Types: Clinical Trial
Randomized Controlled Trial

Glutathione treatment of dyspermia: effect on the lipoperoxidation process
Lenzi A, Picardo M, Gandini L, Lombardo F, Terminali O, Passi S, Dondero F. [Hum Reprod 1994 Nov;9(11):2044-50] We recently introduced reduced glutathione into the therapeutic protocols in some selected cases of dyspermia. This therapy improved semen quality both in a pilot follow-up study and in a double-blind cross-over trial. This improvement was seen in patients with varicocele and germ-free genital tract inflammation, two pathologies in which production of reactive oxygen species or other toxic compounds could have a pathogenic role. Polyunsaturated fatty acids of phospholipids play a major role in membrane constitution and function and are one of the main targets of the lipoperoxidative process. Therefore, to understand the therapeutic action of reduced glutathione, we selected infertile patients and studied the modifications produced by the therapy in seminal parameters, biochemical sperm membrane parameters, and the pattern of fatty acids of phospholipids from blood serum and red blood cell membranes (a model widely accepted as representative of general cell membrane status). The results showed an improvement in both sperm parameters and cell membrane characteristics. This study suggests that biochemical modifications in membrane constitution could explain the seminal results of glutathione therapy. On the other hand, it seems likely that only subjects with systemic membrane disturbances associated with andrological pathologies express this membrane damage in spermatozoa, resulting in dyspermia. This sperm alteration can be partially reversed by glutathione therapy if the structural cell membrane damage is not too severe.
Publication Types: Clinical Trial
Controlled Clinical Trial

A rationale for glutathione therapy
Lenzi A, Gandini L, Picardo M. [Hum Reprod. 1998 Jun;13(6):1419-22.] Department of Medical Pathophysiology, University of Rome La Sapienza, Italy.

Glutathione in spermatozoa and seminal plasma of infertile men
Ochsendorf FR, Buhl R, Bastlein A, Beschmann H. [Hum Reprod 1998 Feb;13(2):353-9] Zentrum Dermatologie und Venerologie, Frankfurt am Main, Germany.
Glutathione has a central role in the defence against oxidative damage; however, the data on glutathione concentrations in the semen of infertile men are limited. This study demonstrated that intracellular glutathione levels of spermatozoa are decreased in certain populations of infertile men.

Status of vitamin E and reduced glutathione in semen of oligozoospermic and azoospermic patients
A. Bhardwaj, A. Verma, S. Majumdar, K. L. Khanduja [Asian J Androl 2000 Sep; 2: 225-228]
Departments of Biophysics and Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Aim: To investigate the status of seminal plasma reduced glutathione (GSH) and vitamin E in three different conditions of spermatogenesis: azoospermia, oligozoospermia and normospermia. Levels of reduced glutathione were also significantly decreased in oligospermic and azoospermic group, and the reduction in azoospermic group (76.73%) was more pronounced than oligozoospermic group (62.07%). Conclusion: The decrease in reduced glutathione, an endogenous antioxidant, levels in azoospermic and oligozoospermic conditions may cause disruption in the membrane integrity of spermatozoa as a consequence of increased oxidative stress.

Relationship between oxidative stress, semen characteristics, and clincial diagnosis in men undergoing infertility investigation
Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ Jr, Agarwal A.
[Fertil Steril 2000;73:459-64]

Oxidative stress in normospermic men undergoing infertility evaluation
Pasqualotto FF, Sharma RK, Kobayashi H, Nelson DR, Thomas AJ Jr, Agarwal A. [J Androl. 2001 Mar-Apr;22(2):316-22] We conclude that oxidative stress is associated with male factor infertility. The presence of oxidative stress in infertile normospermic men may explain previously unexplained cases of infertility otherwise attributed to female factors.

Lipoperoxidation damage of spermatozoa polyunsaturated fatty acids (PUFA): scavenger mechanisms and possible scavenger therapies
Lenzi A, Gandini L, Picardo M, Tramer F, Sandri G, Panfili E. [Front Biosci 2000 Jan 1;5:E1-E15] The lipid metabolism in sperm cells is important both as one of the main sources for energy production and for cell structure. Testis germ cells as well as epididymal maturing spermatozoa are endowed with enzymatic and non-enzymatic scavenger systems to prevent lipoperoxidative damage. Seminal plasma also has a highly specialized scavenger system that defends the sperm membrane against lipoperoxidation and the degree of PUFA insaturation acts to achieve the same goal. Systemic predisposition and a number of pathologies can lead to an anti-oxidant/pro-oxidant disequilibrium. Scavengers, such as GSH, can be used to treat these cases as they can restore the physiological constitution of PUFA in the cell membrane. The results of GSH therapy are presented and discussed.
Publication Types: Clinical Trial

Polyunsaturated fatty acids of germ cell membranes, glutathione and blutathione-dependent enzyme-PHGPx: from basic to clinic
Lenzi A, Gandini L, Lombardo F, Picardo M, Maresca V, Panfili E, Tramer F, Boitani C, Dondero F. [Contraception 2002 Apr;65(4):301-4] Laboratory of Seminology and Immunology of Human Reproduction, Department of Medical Pathophysiology, University of Rome La Sapienza, Italy.

Biochemistry of the induction and prevention of lipoperoxidative damage in human spermatozoa
Storey BT. [Mol Hum Reprod 1997 Mar;3(3):203-13] Center for Research on Reproduction and Women’s Health, University of Pennsylvania Medical Center, Philadelphia 19104-6080, USA.
Lipid peroxidation occurs in human sperm cells with damage to the cell plasma membrane, leading to loss of cytosolic components and hence to cell ‘death’. Human spermatozoa possess the anti-lipoperoxidative defence enzymes, superoxide dismutase (SOD) and glutathione peroxidase plus glutathione reductase (GPX/GRD). The essential role of GPX/GRD is inferred from the observation that inhibition of GPX, either with mercaptosuccinate or with complete oxidation of intracellular reduced glutathione, results in a 20-fold increase in peroxidation rate. Human spermatozoa appear to have enough anti-lipoperoxidative defensive capacity for lifetimes long enough for fertilization but still short enough for ready removal from the female reproductive tract in good time. Too low a defence capacity could lead to male infertility.

Oxidative stress and role of antioxidants in normal and abnormal sperm function
Suresh C. Sikka, Ph.D., HCLD [Frontiers in Bioscience 1, e78-86, August 1,1996]
Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA
Spermatozoa, unlike other cells, are unique in structure, function, and susceptibility to damage by LPO. Mammalian spermatozoa are rich in polyunsaturated fatty acids and, thus, are very susceptible to ROS attack which results in a decreased sperm motility, presumably by a rapid loss of intracellular ATP leading to axonemal damage, decreased sperm viability, and increased midpiece morphology defects with deleterious effects on sperm capacitation and acrosome reaction. Lipid peroxidation of sperm membrane is considered to be the key mechanism of this ROS-induced sperm damage leading to infertility.

Studies on the origin of redox enzymes in seminal plasma and their relationship with results of in-vitro fertilization
Yeung CH, Cooper TG, De Geyter M, De Geyter C, Rolf C, Kamischke A, Nieschlag E.
Mol Hum Reprod. 1998 Sep;4(9):835-9.

Seminal plasma reduces exogenous oxidative damage to human sperm, determined by the measurement of DNA strand breaks and lipid peroxidation
Potts RJ, Notarianni LJ, Jefferies TM. Mutat Res. 2000 Feb 14;447(2):249-56.

Relative impact of oxidative stress on male reproductive function
Sikka SC. [Curr Med Chem. 2001 Jun;8(7):851-62.]

Male infertility: nutritional and environmental considerations
Sinclair S. [Altern Med Rev 2000 Feb;5(1):28-38] Studies confirm that male sperm counts are declining, and environmental factors, such as pesticides, exogenous estrogens, and heavy metals may negatively impact spermatogenesis. A number of nutritional therapies have been shown to improve sperm counts and sperm motility, including carnitine, arginine, zinc, selenium, and vitamin B-12. Numerous antioxidants have also proven beneficial in treating male infertility, such as vitamin C, vitamin E, glutathione, and coenzyme Q10. Acupuncture, as well as specific botanical medicines, have been documented in several studies as having a positive effect on sperm parameters. A multi-faceted therapeutic approach to improving male fertility involves identifying harmful environmental and occupational risk factors, while correcting underlying nutritional imbalances to encourage optimal sperm production and function.

Magnes Res. 1994 Mar;7(1):49-57.

Red cell magnesium and glutathione peroxidase in infertile women–effects of oral supplementation with magnesium and selenium.

Howard JM, Davies S, Hunnisett A.

Biolab Medical Unit, London, UK.

Six women with a history of unexplained infertility or early miscarriage and who had failed to normalize their red blood cell magnesium (RBC-Mg) levels after four months of oral magnesium supplementation (600 mg/day) were investigated for red cell glutathione peroxidase activity (RBC-GSH-Px) and were compared with six age-matched women with a history of unexplained infertility or miscarriage who did normalize their RBC-Mg levels on magnesium supplementation. The six non-normalizers had significantly lower (P < 0.0001) RBC-GSH-Px levels than the six normalizers. After a further two months of 200 micrograms daily oral selenium as selenomethionine and oral magnesium supplements, all six women normalized their RBC-Mg (P < 0.0001) and RBC-GSH-Px (P < 0.0001) levels. All 12 previously infertile women have produced normal healthy babies all conceiving within eight months of normalizing their RBC-Mg levels. The possible relevance of these findings to the medical treatment of infertility is discussed.

PMID: 8054261 [PubMed – indexed for MEDLINE]

NOTE:  THE SELENIUM AND MAGNESIUM supplementation ELEVATED THE GSH (GLUTATHIONE LEVELS). Even more preferrable to consume the glutathione precursors

What are the options to raise glutathione levels?

Drugs NAC and OTC can raise glutathione levels, but their effects are short-lived. These pharmaceutical drugs also have little nutritional value. Whey proteins have excellent nutritional value but usually lack glutathione precursors. The ideal source of dietary cysteine should be natural, nutritional, bioactive, and undenatured and As many of you are aware, whey protein, especially whey protein isolates (over 90% protein), are sometimes referred to as the “perfect” proteins because they contain all the essential amino acids required for your body’s protein synthesis. With a biological value (BV) of over 110, it would be challenging to find a protein utilized more efficiently than Immunocal.

The use of glutathione supplementation fights all kind of diseases from respiratory to auto immune to degenerative diseases.

Without question, the best type of preventive medicine is an optimized immune system, and a critical means to optimize it is by feeding it glutathione.

This is not the same glutathione that you see at the health food store. This is glutathione precursor. It’s very different because glutathione must be made inside your cells and the precursor is the food your cells   require to make its own glutathione as nature intended. That is the most natural and effective approach to boost your immune system.

It’s all natural with NO side effect. 

Want to know if this is for you? 

You can try it for only $10.00 (5-day sample)

Just send me a text here 703-895-0496 with the hashtag “sample” and I will send you a form to fill out, so I know where to send it.

Feel Normal Again!