The content of this article is from the book “The Comprehensive Guide to Glutathione”
by Dr. Jimmy Gutman MD
Mania is usually part of the bipolar condition, but occasionally it occurs alone—outside
the normal cycle of mania and depression. A manic phase is characterized by a heightened
state of arousal, both physically and mentally. There is great instability of mood.
The patient can experience anything from pure euphoria to utter rage. Patients may
hold themselves in high esteem and become grandiose. They are compelled to talk a
lot. Their thoughts race.
They are strongly goal-orientated and may achieve great
things. However, all this high-level activity combined with minimal sleep, eventually
leads to a “crash.” Other negative outcomes include excessive risk-taking with sex, drugs,
shopping, gambling, and inappropriate gift giving. Violent behavior is not uncommon,
As with other psychiatric disorders described in this chapter, increased oxidative
stress and decreased glutathione levels are well documented. Studies using glutathione
or GLUTATHIONE precursors in pure mania are rare.
Berk’s group has done some small, randomized studies in mania with promising results,
but much more work is needed to establish
this as a viable treatment option.