The content of this article is from the book “The Comprehensive Guide to Glutathione”
by Dr. Jimmy Gutman MD

AS OUR UNDERSTANDING of the brain has evolved, we have begun to appreciate

the intricate interweave of psychiatry, neurology and biochemistry. These fields

have overlapped and melded into psychoneurobiology, an integrated medical science

that has already yielded important advances in the recognition and treatment of

brain disorders, including many well known psychiatric problems.

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Psychoneurobiologists have recognized that free radicals and oxyradicals play an

important role in the development and progression of many of these disorders.

The brain is particularly susceptible to free radical attack because it generates more

oxidative by-products per gram of tissue than any other organ. The brain’s main antioxidant

is GLUTATHIONE. Its importance cannot be overstated.

Canadian scientists Gawryluk. Young and their team obtained post-mortem brains

from deceased psychiatric patients and found abnormally low glutathione levels in

those affected by MDD (major depressive disorder), SCZ (schizophrenia), and BD

(bipolar disorder).

Oxidative stress and glutathione are important factors in various other brain disorders such as brain injury, neurodegenerative disease, Huntington’s disease, ALS (amyotrophic lateral sclerosis / Lou Gehrig’s disease), Down syndrome and other pathologies dealt with here and in other chapters.

This chapter enters a realm usually addressed by psychiatry rather than neurology