Acne and Skin disorders

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The immune system coordinates a variety of specialized cells to fight off infection and other threats. The healthy growth and activity of these cells depends upon the availability of glutathione. Glutathione is at the heart of most immune functions, explaining why low levels are seen in many diseases. This is best exemplified by AIDS, which is characterized by a severely compromised immune system.

Raising and maintaining glutathione levels can minimize the risk of these diseases. Although only very ill people are severely deficient in glutathione, those in good or fair health will benefit from glutathione supplementation, especially considering the environmental toxins and drug-resistant bacteria we’re exposed to these days.

The use of glutathione supplementation fights all kind of diseases from respiratory to auto immune to degenerative diseases.

Without question, the best type of preventive medicine is an optimized immune system, and a critical means to optimize it is by feeding it glutathione.

The content of this article is from the book “The Comprehensive Guide to Glutathione”
by Dr. Jimmy Gutman MD FACEP

Glutathione as a dietary supplement.

We must first clarify an important, frequently misunderstood part of the glutathione story. Upon learning about glutathione for the first time, many people go to their health store, buy it, and start dosing themselves. However, while glutathione is freely available in this form, this sort of oral, ingested glutathione will have negligible effects on your health. The product decomposes rapidly in the digestive system and is quickly removed from the gut. Apart from a few very specific instances, glutathione cannot be introduced into the body in this way. It must be made within your cells -which is where it’s naturally found. The effective way to stimulate the production of glutathione is to provide your body with the basic elements it needs to make glutathione by itself. Some pharmaceutical medications, such as N-acetyl-cysteine (NAC), have been developed to provide these recursors. There are also natural ways to increase glutathione levels, in particular the use of denatured (bioactive) whey proteins. These are discussed throughout this website.

GLUTATHIONE AND SKIN DISEASE

From the book “Glutathione Your Key to Health” Jimmy Gutman MD/Stephen Schettini

SKIN DISORDERS

What is the largest organ in the body? Most people think it’s the liver or even the intestine, but in fact it’s the skin. Besides providing a protective bar rier against the environment, the skin performs a large number of important functions, endocrinological, thermoregulatory, immunological, toxicological and circulatory.

The skin can host a huge variety of diseases and disorders and about one third of North Americans will experience some sort of skin problem. Skin disorders also affect patients differently, especially in their psychological reactions to the disease. Firstly, the fact that they can actually see the problem makes it hard to forget; secondly they are often nervous about the actual or perceived reaction of others, and the social or interpersonal consequences.

GLUTATHIONE AND SKIN DISEASE

Given the number of functions served by the skin, it is no surprise that glutathione is involved in many skin problems. role of glutathione in detoxification and prevention of radiation damage in other tissues is well-known. It plays just as vital a role here. Low levels of glutathione have been documented in many types of skin disease, including:

PsoriasisAtopic dermatitis
EczemaSeborrheic dermatitis
VasculitisContact dermatitis
Mycosis fungoidesDermatitis herpetiformis
PolymyositisPemphigoid
SclerodermaAcne conglobata
SLE (lupus)Acne vulgaris

This chapter focuses on psoriasis, dermatitis and ultra-violet radiation damage.

PSORIASIS

Psoriasis is a common, chronic recurrent skin condition characterized by white or red patches of skin on the legs, knees, arms, elbows, ears, scalp. It may consist of one or two inconspicuous small patches or cover the body. This can affect the joints and occasionally even lead to disabling arthritis However, such extreme cases are rare, and general health for most psoriatic patients is good. Lesions are typified by an overgrowth of skin cells which multiple up to ten times faster than normal skin cells. overgrowth continues an leads to the classic raised, silvery, flaky appearance of the condition.

The actual cause of psoriasis remains unknown. It may be triggered by different factors in different people. Fair-skinned individuals, in particular, may have a genetic predisposition to it. It certainly has something to do with the immune response itself. Attacks or flare-ups can be triggered by emotional or physical stress, illness, injury, infection, drug and alcohol abuse, obesity, and many different chemicals. The other chapters of this book describe the critical role of glutathione in many of these processes.

One source of relief for psoriatic patients is travel to a healing environment. The Dead Sea in Israel is particularly popular. A medical facility — The Dead-Sea Psoriasis Treatment Center — has been set up specifically for this purpose. Researchers have tried to understand why this particular area seems to help. High levels of sunlight seem to affect psoriasis positively. Most interestingly, the drinking water in the area is very high in selenium. A local research team explains that the best indicator of selenium bioactivity is patients’ glutathione peroxidase levels. Compared to a control group and to their own initial glutathione levels, patients spending weeks in this treatment center increased glutathione peroxidase levels, often as much as 50%.

Psoriasis patients suffer from abnormal glutathione enzyme activities, and researchers have linked the disease to high levels of free radicals. Lowered glutathione activity results in greater damage. The clinical results of raising glutathione in this disease are promising and more studies are underway.

Case Study

Roland is a 44-year-old energetic and sociable business entrepreneur who suffered from psoriasis for ten years. Itchy, scaly eruptions often covered his entire body, and aggressive scratching led to bleeding and scabbing. His dermatologist tried many different treatments including strong topical corticosteroids and methotrexate tablets, which he had to discontinue due to side-effects. Ultraviolet light therapy was suggested, but having the financial means, Roland preferred frequent trips to Mexico and the Caribbean to sitting in artificial light. Having done significant homework on his condition, he concluded that the psoriasis was caused by an immune dysfunction. He started taking 40 grams/day of bioactive whey protein isolate to raise his glutathione levels. Within two weeks he was free of bleeding and scabs and described his scaling as 75% improved.

DERMATITIS

Dermatitis is a general term meaning inflammation of the skin. It is caused by a wide range of different ailments. Toxins or irritants can lead to contact dermatitis. Allergies can lead to allergic or atopic dermatitis. Many intestinal  or immunological diseases can lead to such forms as dermatitis herpetiformis. Overproduction of oils in the skin can lead to seborrheic dermatitis. Dermatitis can be triggered by stress or illness. Overly hot, dry, cold or wet environments also promote dermatitis. All are characterized by red itchy skin and in extreme cases blistering, crusty or oozing lesions. Almost all of these conditions have been linked to abnormal glutathione activity.

In both irritant contact dermatitis and allergic contact dermatitis, glutathione levels fall both in the skin and the whole body. A group of Japanese dermatologists inhibited glutathione production with BSO and found that both allergic and irritant contact dermatitis rashes became more severe. They link this both to the detoxification abilities of glutathione(GSH) and to its effect on the immune system.

Several research teams have shown that glutathione -precursors help the immune system respond to contact sensitivity. A Swedish team using the glutathione enhancing drugs NAC and DiNAC demonstrated significant results with contact and delayed hypersensitivity reactions. G. Senaldi of the University of Geneva successfully used both topical and oral NAC to experimentally treat contact and irritant dermatitis. His team suggested that a similar approach may benefit cancer patients suffering from skin inflammation secondary to TNF-alpha (tumor necrosis factor-alpha), an inflammatory side-effect of cancer.

Contact dermatitis often arises from the use of cosmetics, including makeup, skin creams, eyeliners, and other products. One particular culprit is a group of preservatives/sanitizers known as MCI/MI (methyl-chloro-isothiazolinone/ methyl-isothiolinone). A group of Swedish occupational and environmental dermatologists found that the addition of as little as 2% glutathione to these emollients deactivates the MCI/MI.

Thimerosol is another popular preservative used in toiletries, including contact lens solutions. It is known to cause skin and eye reactions, probably because of its organomercury content. At Rome’s Dermatological Institute, B. Santucci showed that adding I-cysteine or glutathione to solutions containing thimerosol reduced or prevented reactions to this chemical.

AIDS patients are more prone to skin disease than others. These conditions include Karposi’s sarcoma, seborrheic dermatitis, and others. As we discussed earlier, most AIDS patients are glutathione-deficient, a factor that contributes to these skin conditions. S. Passi and A. Morrone in Italy and other teams have shown a deficiency of glutathione peroxidase activity both in HIV -positive patients and in otherwise healthy individuals with seborrheic dermatitis.

An interesting experiment was carried out at the Welsh School of Pharmacy. examined the dermatitis-inducing chemicals of plants such as poison ivy and poison oak and found that most inflammation was due to free radicals. Using the glutathione-precursor OTZ they were able to reduce the irritation and sensitizing effect of these noxious compounds.

        SUN AND ULTRAVIOLET RADIATION SKIN DAMAGE                   

By far the most common cause of abnormal aging, wrinkling, and cancer of the skin is sun exposure and ultraviolet radiation. We may pay later in life for the ‘healthy’ bronzed glow of our youth. The skin-aging consequences of tanning lead many people to plastic surgery. But most face-lifts would be unnecessary if these patients had avoided tanning when they were younger. Many skin cancers that appear in adult life may actually be initiated by severe sunburn as a child. well-known ozone layer in the atmosphere blunts the damaging effects of ultraviolet A and B radiation found in sunlight. The ozone depletion which has so concerned scientists in recent years has already increased the number of skin cancer patients. We may yet witness an even more dramatic increase in the years to come. Physicians are treating sunburn in more and more patients who claim they have never before been so dramatically affected by sun exposure.

Radiation releases high levels of hydroxyl-radicals in the skin. These are the most toxic free radicals known to man. Such radiation comes from sunlight UV-A and UV- B, sun lamps, radiotherapy treatment, and X-rays. The damaging radicals are normally neutralized by glutathione, but overexposure overwhelms this protective system and glutathione levels can fall, resulting in even more damage. For this reason, doctors have considered using antioxidant supplementation to protect the skin. Studies using various antioxidants have had mixed results. Research into elevated glutathione levels has been much more encouraging.

P. Baas and his team at The Netherlands Cancer Institute used halogen lamps to sensitize their patients to light and showed that sensitivity decreased when the patients were pretreated with NAC to raise glutathione levels. Another Dutch team at the Department of Medicinal Photochemistry, Leiden University looked at various oral and topical products and their capacity to decrease UV skin damage. found that NAC, whether ingested or applied to the skin was a practical means of protecting from UV-B radiation damage.

French researchers at Joseph Fourier University in Grenoble examined how effectively various glutathione precursors could limit UV-A radiation damage. The researchers conclude that elevated glutathione levels protect against UV-A damage.

Similar studies at Harvard University and Hirosaki University in Japan investigated the way UV-B radiation causes sunburn. Using animal subjects they first showed that glutathione depletion resulted in significantly greater sunburn damage. Further studies with orally administered esterified glutathione raised glutathione levels and resulted in less damage. Other Japanese experiments using higher doses of uv-radiation on their animals showed that pre-treatment with glutathione esters could actually decrease the number of skin tumors that developed much later on.

A German team at the University of Berlin studied the effect of UV-B damage on people with an inherited defect in a glutathione enzyme called glutathione S-transferase. The glutathione-impaired group suffered significantly more intense damage than the control group, so it seems that inherited glutathione-transferase deficiencies determine how sensitive an individual is to sunlight.

UV-B exposure not only damages skin, at high doses, it affects the immune system itself by suppressing the local and general functioning of T-cell lymphocytes. Substances that deplete glutathione levels decrease this response even more, and substances that elevate glutathione levels protect it. D.P. Steenvoorden and his team at the Amsterdam Center for Drug Research used BSO to lower glutathione levels and NAC or glutathione-esters to raise them, demonstrating that elevated glutathione levels provide protection against UV-B immunosuppression.


Case study

The 61-year-old Canadian Charles loved boating. His dream was to retire and spend most of his time on the water, traveling the coasts. Tall, handsome, and fair-skinned, he was unfortunately prone to sunburn. Despite sunscreens and hats, being on the water often left him unprotected and his complexion grew ruddy and inflamed. His physician was worried about the possible development of pre-cancerous sun-induced lesions on his face. Charles had already started taking selenium, alpha-lipoic acid, and lycopenefor a potential prostate problem. After several weeks he noticed his tendency to burn was significantly decreased, despite some ‘accidental’ exposure. In two months his in-the-sun complexion wasn’t so different from his winter complexion.

CONCLUSION

Low glutathione levels characterize many skin diseases. Practical applications with glutathione-raising substances have been studied in the treatment of several diseases. There has been success in some but not all cases of psoriasis. This may reflect the multiple and various causes of this disease. Many of the diseases that fall under the very general definition of dermatitis may be positively affected by raised glutathione levels. Glutathione is of extreme importance as a protective agent against the ultraviolet radiation of the sun.

Glutathione as a dietary supplement.

Drugs NAC and OTC can raise glutathione levels, but their effects are short-lived. These pharmaceutical drugs also have little nutritional value. Whey proteins have excellent nutritional value but usually lack glutathione precursors. The ideal source of dietary cysteine should be natural, nutritional, bioactive, and undenatured and As many of you are aware, whey protein, especially whey protein isolates (over 90% protein), are sometimes referred to as the “perfect” proteins because they contain all the essential amino acids required for your body’s protein synthesis. With a biological value (BV) of over 110, it would be challenging to find a protein utilized more efficiently than Immunocal.

The use of glutathione supplementation fights all kind of diseases from respiratory to auto immune to degenerative diseases.

Without question, the best type of preventive medicine is an optimized immune system, and a critical means to optimize it is by feeding it glutathione.

This is not the same glutathione that you see at the health food store. This is glutathione precursor. It’s very different because glutathione must be made inside your cells and the precursor is the food your cells   require to make its own glutathione as nature intended. That is the most natural and effective approach to boost your immune system.

It’s all natural with NO side effect. 

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Just send me a text here 703-895-0496 with the hashtag “sample” and I will send you a form to fill out, so I know where to send it.

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